DETAILS, FICTION AND LIGAZ SLOTS

DNA ligases seal 5′-PO4 and 3′-OH polynucleotide ends by way of three nucleotidyl transfer steps involving ligase-adenylate and DNA-adenylate intermediates. DNA ligases are necessary guardians of genomic integrity, and ligase dysfunction underlies human genetic ailment syndromes. Crystal constructions of DNA ligases sure to nucleotide and nucle